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eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
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2/2002
vol. 104
 
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abstract:
Experimental research

The influence of the nitric synthase inhibitor (L-NAME) on the intraocular pressure in endotoxin induced uveitis in rats

Stanisław Szymaniec
1
,
Marta Misiuk-Hojło
2

  1. Z Zakładu Terapii Doświadczalnej Instytutu Immunologii i Terapii Doświadczalnej Polskiej Akademii Nauk we Wrocławiu
  2. Z Kliniki i Katedry Okulistyki Akademii Medycznej we Wrocławiu
Online publish date: 2002/06/29
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We studied the influence of the nitric synthase inhibitor (L-NAME) on the induction of uveitis in Wistar rats. The inflammation was induced by a footpad injection of endotoxin in rat. The clinical signs were evaluated in a slit-lamp, the intraocular pressure was measured using Tono Pen tonometer. We showed, that in endotoxin-induced uveitis the intraocular pressure elevation was observed and that L-NAME application reduced the inflammation and the level of the intraocular pressure.
keywords:

nitric oxide, experimental uveitis

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