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ISSN: 1233-9687
Polish Journal of Pathology
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abstract:
Case report

Sebaceous vs. lipid-rich carcinoma of the breast. Clinicopathological characteristics and correlations – a report of 2 cases and a literature review

Nikola Živković
1
,
Ana Cvetanović
2
,
Miloš Kostić
3
,
Maja Jovičić Milentijević
1
,
Miodrag Djordjević
4
,
Tijana Denčić
1
,
Julija Cvetković
1
,
Mirjana Ćuk
5

  1. Department of Pathology, Faculty of Medicine Niš, University of Niš, Serbia
  2. Department of Oncology, Faculty of Medicine Niš, University of Niš, Serbia
  3. Department of Microbiology and Immunology, Faculty of Medicine Niš, University of Niš, Serbia
  4. Department of Surgery, Faculty of Medicine Niš, University of Niš, Serbia
  5. Department of Pathology, Faculty of Medicine Foča, University of East Sarajevo, Republic of Srpska, Bosnia and Herzegovina
Pol J Pathol 2024; 75 (3)
DOI: https://doi.org/10.5114/pjp.2024.143114
Online publish date: 2024/09/20
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Primary sebaceous and lipid-rich carcinomas are extremely rare. Sebaceous carcinoma cells are large and oval with light, partially vacuolated cytoplasm. The second population consists of cells located mainly on the peripheral parts of tumour beaches. Those cells are of smaller calibre and are fusiform in appearance. Lipid- rich carcinoma is made up of multiple cell populations. The predominant cell type is with a distinctly light, vacuolated, and partially optically clear cytoplasm. Pathohistological analysis may be overlapping. On one side there is a tumour with a relatively excellent prognosis, and on the other, a highly aggressive carcinoma with a tendency for early metastases.
keywords:

breast, immunohistochemistry, lipid-rich carcinoma, sebaceous carcinoma
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