eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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SCImago Journal & Country Rank
3/2022
vol. 26
 
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abstract:
Original paper

Outcome of docetaxel in treatment of metastatic hormone-sensitive prostate cancer and correlation with hemoglobin, albumin, lymphocyte and platelets score

Heba F. Taha
1
,
Dalia Hamouda Elsayed
1
,
Reham Salem
2
,
Doaa Mandour
2
,
Mohammed Bayomy
2
,
Hayam Rashed
3
,
Mostafa Kamel
4
,
Mohamed Elderey
4
,
Ola M. Elfarargy
1

  1. Medical Oncology Department, Zagazig University, Zagazig, Egypt
  2. Clinical Oncology and nuclear medicine department, Zagazig University, Zagazig, Egypt
  3. Pathology Department, Zagazig University, Zagazig, Egypt
  4. Urology Department, Zagazig University, Zagazig, Egypt
Contemp Oncol (Pozn) 2022; 26 (3): 196–203
Online publish date: 2022/10/24
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Introduction
We aimed to evaluate the outcome of treatment with docetaxel plus androgen deprivation therapy (ADT) in newly diagnosed patients with metastatic high tumor burden hormone-sensitive prostate cancer (mHSPC) and correlated the outcome with hemoglobin, albumin, lymphocyte and platelets (HALP) score.

Material and methods
Six cycles of docetaxel plus ADT were given to 50 patients with high burden mHSPC. Baseline HALP score was calculated and disease outcome was tabulated; moreover, the prognostic impact of the HALP score in response to treatment and survival was calculated.

Results
We found a significant association between high HALP score and response to treatment where a higher rate of complete response occurred in patients with a high HALP score than in patients with a low HALP score (53.8% vs. 5.4% respectively, p-value = 0.001). Patients with ≥ 12-month-duration castration-resistant prostate cancer (CRPC) had a significantly higher HALP score compared to patients with a lower HALP score (84.6% vs. 35.1% respectively, p-value = 0.002); 18-month-duration CRPC-free survival was significantly greater in patients with higher HALP score than patients with a lower HALP score (23.1% and 5.4% respectively, p-value < 0.001). Patients with a high HALP score had insignificantly higher mean overall survival than patients with a low HALP score (mean: 22.91 and 20.66 months respectively, p-value = 0.230).

Conclusions
Our results confirmed the benefits of treatment with docetaxel plus ADT in high-burden mHSPC with accepted tolerance. HALP score was found to be an independent predictive factor for benefit from therapy; we can apply it as an easy way to stratify patients for appropriate selection of treatment for better tolerance and outcome.

keywords:

metastatic prostatic cancer, high burden, hormone-sensitive, docetaxel, HALP score

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