eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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4/2024
vol. 41
 
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abstract:
Review paper

Dermatophagoides pteronyssinus proteins and their role in the diagnostics and management of house dust mite allergy: exploring allergenic components

Magdalena Choina
1, 2, 3
,
Krzysztof Kowal
1, 2
,
Ewa Markut-Miotła
4
,
Emilia Majsiak
5

  1. Department of Experimental Allergology and Immunology, Medical University of Bialystok, Poland
  2. Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland
  3. Polish-Ukrainian Foundation of Medicine Development, Lublin, Poland
  4. Department of Pulmonary Diseases and Children Rheumatology, Medical University of Lublin, Poland
  5. Department of Health Promotion, Faculty Health of Sciences, Medical University of Lublin, Poland
Adv Dermatol Allergol 2024; XLI (4): 339-349
DOI: https://doi.org/10.5114/ada.2024.142390
Online publish date: 2024/08/21
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Component-resolved diagnostics enables the detection of allergen-specific immunoglobulins E (asIgE) to house dust mite (HDM) proteins, which may help clinicians to face the difficulties in diagnostics of HDM allergy. Currently, almost 40 proteins of Dermatophagoides species, that are able to bind asIgE, have been identified, and this number will certainly increase. The association between sensitisation to particular molecules and allergy symptoms is extensively studied. This investigation enables us to identify HDM molecules that promote respiratory, skin, or food allergies, and it could help us predict the possible course of allergic diseases. The individual repertoire of asIgE improves our understanding of immunological response, which underlies allergy symptoms, and helps to form individual therapeutic regimens. This review provides clinicians with information on Dermatophagoides pteronyssinus proteins available in commercial arrays, and their role in the diagnostics and management of HDM allergy.
keywords:

component-resolved diagnostics, house dust mites, sensitisation
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