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Central European Journal of Immunology
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4/2021
vol. 46
 
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Letter to the Editor

Analysis of FcαRI rs16986050 polymorphism in relation to autoimmune responses in dermatitis herpetiformis: an issue probing study

Justyna Gornowicz-Porowska
1
,
Michał J. Kowalczyk
2
,
Agnieszka Seraszek-Jaros
3
,
Monika Bowszyc-Dmochowska
4
,
Elżbieta Kaczmarek
3
,
Katarzyna Łącka
5
,
Ryszard Żaba
2
,
Marian Dmochowski
6

  1. Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis; Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poland
  2. Department of Dermatology and Venereology, Poznan University of Medical Sciences, Poland
  3. Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, Poland
  4. Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poland
  5. Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poland
  6. Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poland
(Cent Eur J Immunol 2021; 46 (4): 492-493)
Online publish date: 2021/11/29
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- Analysis of FcaRI.pdf  [0.10 MB]
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Dear Editor,

Dermatitis herpetiformis (DH) is an autoimmune blistering dermatosis (ABD) associated with gluten intolerance [1, 2]. It is postulated that DH is a blistering skin manifestation of gluten-sensitive enteropathy (celiac disease). However, the precise molecular relationship is still not fully understand. The presence of various proteins (epidermal transglutaminase – eTG, tissue transglutaminase – tTG, nonapeptides of gliadin – npG) and the lack of precise identification of a specific individual molecule [3] suggests that DH is unlikely to be a classical autoantigen-driven autoimmune disease. Thus, specific genetic susceptibility, as well as environmental factors, is implicated in DH induction and progression. The involvement of the impaired human immunoglobulin A (IgA) Fc receptor (FcαRs) regulatory system is proposed, which may be linked to the activation of disease. The affinity of IgA Fc receptors (FcRs) to the autoimmune response in DH may vary based on single-nucleotide polymorphisms (SNPs) influencing the course and severity of the disease. Based on our previous studies [3, 4] FcαI/CD89 seems to be the most promising candidate associated with the immune response during DH development. FcαI/CD89 is a transmembrane glycoprotein binding both IgA1 and IgA2. CD89 shows abundant expression on human neutrophils and mediates inflammatory responses to IgA-immunocomplexes. The functional polymorphism 844 A>G in FCAR/CD89 (rs16986050) is associated with a proinflammatory response, and with a higher percentage of cells with the formation of neutrophil extracellular trap (NET) [5]. However, there seem to be no data or consensus concerning FCAR/CD89 polymorphisms in DH.

This study aimed to investigate the role of the FCAR/CD89 SNP (rs16986050) missense polymorphism in the genetic predisposition to DH susceptibility concerning the autoimmune response.

In total, 48 subjects were investigated: 17 DH patients with an active skin rash before initiation of treatment and 31 healthy individuals (a local bioethical committee agreement, 541/13, Poland, 2013). The examined material consisted of perilesional skin tissues, sera, and EDTA-aspired whole blood. ELISA tests, direct immunofluorescence (DIF), TaqMan SNP Genotyping Assay, and statistical analysis were performed.

The greatest relative risk (odds ratio, OD) was reported for GG (rs16986050 of CD89) homozygotes (Table 1), albeit statistically insignificant (p = 0.3306). There was no statistically significant deviation from the Hardy-Weinberg equilibrium. There was no statistically significant relation between rs16986050 of CD89 and IgA tissue-bound antibodies. There were no statistically significant differences between the genotypes of rs16986050 and specific anti- tTG IgA circulating autoantibodies.

Table 1

Distribution of alleles and genotypes of rs16986050 in the examined DH population and healthy controls

rs16986050DH (n = 17)
n (%)
Controls
(n = 31) n (%)
OR
(95% CI)
p value
Allele
A23 (68)46 (74)0.73
(0.29-1.82)
0.3255
G11 (32)16 (26)2.00
(0.85-4.70)
Genotypes
AA9 (53)17 (55)0.92
(0.28-3.04)
1.000
AG5 (29)12 (39)0.66
(0.18-2.35)
0.7531
GG3 (18)2 (6)3.11
(0.46-20.77)
0.3306
pHW0.17620.9517

[i] DH – dermatitis herpetiformis, n – number of patients, OR – odds ratio, CI – confidence interval, pHW – Hardy-Weinberg p-value

The results of this issue-probing study suggest that the rs16986050 polymorphism, located in the coding region of CD89, is not associated with DH autoimmunity. Altogether, we could not demonstrate a role for the CD89 844A>G variant in the DH autoimmunity response, either as a locally dependent process or a systemic reaction. Nevertheless, it remains to be elucidated whether rs16986050 influences autoinflammation (direct neutrophil stimulation) rather than autoimmunity in DH.

Acknowledgments

This work was undertaken in conjunction with the activities of the European Reference Network-Skin.

Notes

[2] Conflicts of interest The authors declare no conflict of interest.

References

1 

Görög A, Antiga E, Caproni M, et al. (2021): S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol 35: 1251-1277.

2 

Collin P, Salmi TT, Hervonen K, et al. (2017): Dermatitis herpetiformis: a cutaneous manifestation of coeliac disease. Ann Med 49: 23-31.

3 

Gornowicz-Porowska J, Seraszek-Jaros A, Bowszyc-Dmochowska M, et al. (2017): Immunoexpression of IgA receptors (CD89, CD71) in dermatitis herpetiformis. Folia Histochem Cytobiol 55: 212-220.

4 

Gornowicz-Porowska J, Seraszek-Jaros A, Bowszyc-Dmochowska M, et al. (2017): A comparative study of expression of Fc receptors in relation to the autoantibody-mediated immune response and neutrophil elastase expression in autoimmune blistering dermatoses. Pol J Pathol 68: 109-116.

5 

Wu J, Ji C, Xie F, et al. (2007): FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA. J Immunol 178: 3973-3982.

Copyright: © 2021 Polish Society of Experimental and Clinical Immunology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
 
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